Dr. Lupo specializes in orthopaedic surgery and joint replacement. He is certified and the director of robotic joint replacement for AHN Saint Vincent since 2015.

He specializes in robotic minimally invasive total knee replacements, partial joint replacements, and direct anterior hip replacement surgery. He also performs traditional and reverse shoulder replacements, as well as minimally invasive arthroscopy of the shoulder and knee, including: rotator cuff tears, shoulder labral tears, should instability, knee meniscus injuries, knee ligament and cartilage injuries. He speaks English